Status:
COMPLETED
Trial on The Efficacy of Hypertonic Saline on Non-CF CSLD.
Lead Sponsor:
University of Malaya
Conditions:
Bronchiectasis
Eligibility:
All Genders
3-18 years
Phase:
PHASE4
Brief Summary
To determine the efficacy of nebulized 5% hypertonic saline on cough severity and quality of life, in children with non-CF CSLD. Secondary Aims: To determine the: 1. Efficacy of nebulized 5% hypert...
Detailed Description
Primary Aim: To determine the efficacy of nebulized 5% hypertonic saline on cough severity and quality of life, in children with non-CF CSLD. Here the investigators will be using validated pediatric...
Eligibility Criteria
Inclusion
- Patients \< 18 years old
- Followed up in the paediatric respiratory clinic of UMMC with a diagnosis of CSLD
Exclusion
- Incomplete data or refusal to participate
- Unwell and/or unable to stop HS and/or antibiotics of any preparation other than azithromycin ( EOD
- On supplementary oxygen/home ventilation
- Poorly controlled asthma (as in the GINA guidelines) or bronchoconstriction that precedes the use of hypertonic saline.
- Oral antibiotics for less than 4 weeks before randomization for medication.
- Fall in PEFR \> 20% post 5% HS challenge test or a positive HS challenge test in young children, as mentioned below.
Key Trial Info
Start Date :
February 4 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 28 2023
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT04765033
Start Date
February 4 2021
End Date
August 28 2023
Last Update
December 1 2023
Active Locations (1)
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1
University Malaya Medical Centre
Kuala Lumpur, Lembah Pantai, Malaysia, 59100