Status:
COMPLETED
Mirabegron and Physiological Function in Cold Environments
Lead Sponsor:
Indiana University
Collaborating Sponsors:
Office of Naval Research (ONR)
Conditions:
Resting Energy Expenditure
Thermogenesis
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
PHASE2
Brief Summary
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete t...
Detailed Description
This is a randomized, double-blind, placebo-controlled, cross-over experimental design. Participants will be asked to complete 5 visits to the laboratory; one informed consent/screening visit and 4 st...
Eligibility Criteria
Inclusion
- Men and women
- 18-40 years old
- Participate in 150 minutes or more of at least moderate intensity exercise per week during the previous 2 years
Exclusion
- diagnosed autonomic disease
- diagnosed cardiovascular disease
- diagnosed metabolic disease
- diagnosed neurologic disease
- diagnosed endocrine disease
- diagnosed respiratory disease
- diagnosed liver dysfunction
- diagnosed kidney dysfunction
- Women who are pregnant or breastfeeding
- Individuals currently taking a medication (with the exception of birth control, including hormonal contraception) that cannot be safely discontinued for 5 biological half-lifes prior to each study visit based on consultation with the study physician.
- Current tobacco or electronic cigarette use or consistent use within the last 1 year
Key Trial Info
Start Date :
November 30 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 27 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04766021
Start Date
November 30 2021
End Date
April 27 2023
Last Update
July 12 2024
Active Locations (1)
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1
Indiana University
Bloomington, Indiana, United States, 47405