Status:
COMPLETED
Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
Lead Sponsor:
Tulane University
Collaborating Sponsors:
Louisiana Clinical and Translational Science (LA CaTS) Center Clinical Research Resources Core
Conditions:
Atrial Fibrillation
Arrhythmia
Eligibility:
FEMALE
20-80 years
Brief Summary
The study will analyze blood from volunteers to determine whether there is an underlying epigenetic cause of the inflammation of the heart associated with atrial fibrillation (AF) and its progression ...
Detailed Description
Blood samples will be collected from 30 female participants as follows: 10 women between the ages of 50 - 80 years diagnosed with AF as evidenced by rhythm strips or written documentation; 10 healthy ...
Eligibility Criteria
Inclusion
- Subjects aged 18 or above,
- Control Group scheduled for routine annual health check-up and healthy blood donors without any documentation of cardiovascular disease or other serious immune-related illnesses, such as diabetes, hypertension, autoimmune arthritis etc
- healthy women subjects between the ages of 50-80 years
- healthy women subjects between the ages of 20-30 years.
- Study Patients -women between the ages of 50 - 80 years diagnosed with AF as evidenced by rhythm strips or written documentation.
Exclusion
- Previous left atrial ablation or any type of valvular surgery
- Patients who are taking medications like Ibuprofen, Toradol, Naproxen and other common over-the -counter NSAIDs.
- Women who are pregnant
- Terminally ill patients
Key Trial Info
Start Date :
October 22 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 16 2024
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT04766814
Start Date
October 22 2021
End Date
February 16 2024
Last Update
April 25 2024
Active Locations (1)
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1
Tulane University Medical Center
New Orleans, Louisiana, United States, 70112