Status:
COMPLETED
Renal Considerations in the Heat Stress Recommendations
Lead Sponsor:
Indiana University
Collaborating Sponsors:
State University of New York at Buffalo
Conditions:
Hot Weather; Adverse Effect
Kidney Dysfunction
Eligibility:
All Genders
18-44 years
Phase:
NA
Brief Summary
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused b...
Eligibility Criteria
Inclusion
- Men and women
- 18-44 y old
- Body mass index ≤35.0 kg/m2
- Self-reported to be healthy.
Exclusion
- Not within defined age range
- Estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2
- Deemed highly active according to the physical activity questionnaire (i.e., \>3500 MET\*min/wk)
- Body mass index \>35.0 kg/m2
- Current or history of any renal disease, heart disease, stroke, immune or autoimmune disease, and/or gastrointestinal disease/surgery
- Hypertension during screening (systolic blood pressure \>139 or diastolic blood pressure \>89)
- Using medications that blunt the physiological response to exercise (e.g., beta blockers)
- Prescription medication with a known side effect of impaired temperature regulation or fluid balance (e.g., diuretics)
- Positive pregnancy test at any time during the study or breast feeding
- Current tobacco or electronic cigarette use or consistent use within the last 2 years
- Inability to safely complete the peak oxygen uptake test
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 4 2023
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT04767347
Start Date
March 1 2021
End Date
May 4 2023
Last Update
November 8 2023
Active Locations (1)
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1
School of Public Health
Bloomington, Indiana, United States, 47405-7109