Status:
COMPLETED
Role of LncRNA H19 in The Regulation of IGF-1R Expression
Lead Sponsor:
Mansoura University
Conditions:
Hepatocellular Carcinoma
Type 2 Diabetes
Eligibility:
All Genders
40+ years
Brief Summary
Hepatocellular carcinoma (HCC) is a common cancer that poses a heavy economic burden on the healthcare system. In Egypt, it is the most common cause of mortality and morbidity-related cancer. Diabetes...
Detailed Description
Hepatocellular carcinoma (HCC) is a common cancer that poses a heavy economic burden on the healthcare system. It represents the fourth and sixth most common cancer in Egypt and worldwide respectively...
Eligibility Criteria
Inclusion
- • HCC cases (group I):
- Inclusion criteria:
- \- Patients aged 40 years or older with a confirmed diagnosis of HCC through triphasic CT and/or dynamic MRI (European Association for the Study of the Liver, 2012).
- Exclusion criteria:
- Patients who underwent previous cancer-directed treatment (radiation and/or chemotherapy).
- Patients with any other systemic disease (Renal disease, other primary tumors).
- T2DM cases (group II):
- Inclusion criteria:
- \- Clinically diagnosed T2DM patients aged 40 years or older frequenting Mansoura Specialized Medical Hospital.
- Exclusion criteria:
- Patients with previous or current malignancies.
- Patients with diabetic complications (Diabetic retinopathy, neuropathy, nephropathy).
- Patients with other systemic diseases.
- HCC \& T2DM cases (group III):
- Inclusion criteria:
- \- Patients aged 40 years or older with a confirmed diagnosis of HCC through triphasic CT and/or dynamic MRI and who are clinically diagnosed to have T2DM.
- Exclusion criteria:
- Patients who underwent previous cancer-directed treatment (radiation and/or chemotherapy).
- Patients with any other systemic disease.
- • Controls (group IV):
- Apparently healthy, age, and gender-matched subjects.
- No history of malignant disease, diabetes, or HCV.
Exclusion
Key Trial Info
Start Date :
January 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 4 2022
Estimated Enrollment :
101 Patients enrolled
Trial Details
Trial ID
NCT04767750
Start Date
January 1 2020
End Date
April 4 2022
Last Update
April 7 2022
Active Locations (2)
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1
Gastroenterology Center, Mansoura University
Al Mansurah, Dakahliya, Egypt, 35516
2
Specialized Medical Hospital, Mansoura University
Al Mansurah, Dakahliya, Egypt, 35516