Status:
UNKNOWN
The Culture of Ovarian Cancer Organoids and Drug Screening
Lead Sponsor:
Chongqing University Cancer Hospital
Conditions:
Ovarian Cancer
Eligibility:
FEMALE
18-70 years
Brief Summary
The tumor organoids platform can provide the precise genetic information and phenotype, as well as the heterogeneity of the tumor, thus provide information on drug sensitivity specific to the patient....
Detailed Description
Tissue will be received from operative specimens( primary ovarian carcinoma) at time of primary cytoreductive surgery.Ovarian cancer(OC) organoids will be then cultured. Organoids will be validated wi...
Eligibility Criteria
Inclusion
- Ovarian cancer patients who will accept primary cytoreductive surgery, with histopathological type: low/high grade serous carcinoma, clear cell carcinoma, endometrioid carcinoma, mucinous carcinoma.
- ECOG score 0\~1,age 18\~70 years old
- Expected survival over 6 months
- The serum or urine pregnancy test must be negative within 7 days before enrollment for the women of childbearing age who should agree that contraception must be used during the trial
- CBC：Hb≥70g/L、WBC≥3.5×109/ L 、ANC≥1.5×109/L、PLT≥80×109/L；
- Serum ALT≤2×UL, AST≤2×ULN；Serum creatinine≤1.5×ULN；
Exclusion
- Activity or uncontrol severe infection
- Liver cirrhosis, Decompensated liver disease
- History of immune deficiency, including HIV positive or suffering from congenital immunodeficiency disease
- Chronic renal insufficiency or renal failure
- Has combined with other malignant tumor which diagnosed within 5 years and/or needed to be treated
- Myocardial infarction, severe arrhythmia and NYHA (New York heart association)≥2 for congestive heart failure
- During the treatment for complications, the drugs which lead to serious liver and/or kidney function impairment need to be used, such as tuberculosis
Key Trial Info
Start Date :
April 12 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04768270
Start Date
April 12 2022
End Date
December 31 2024
Last Update
August 31 2023
Active Locations (1)
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1
Chongqing Cancer Hospital
Chongqing, Chongqing Municipality, China, 400030