Status:
RECRUITING
Serial Advanced Magnetic Resonance Imaging Scan for Guidance of Personalized Adaptive Radiotherapy for High Grade Glioma
Lead Sponsor:
M.D. Anderson Cancer Center
Conditions:
Malignant Glioma
Eligibility:
All Genders
18+ years
Brief Summary
This study examines whether repeated magnetic resonance imaging (MRI)s scan helps identify changes in the tumor during radiation and chemotherapy treatment in patients with high grade glioma. Addition...
Detailed Description
PRIMARY OBJECTIVES: I. To compare the radiation dosimetric coverage of the surgical cavity and any residual tumor when the immediate post-operative MRI is used versus (vs.) newly acquired MRI prior t...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- All patients with histologic confirmation of high grade glioma
- Patients must be age \>= 18 years
- Patients must sign informed consent indicating that they are aware of the investigational nature of this study in keeping with the policies of the hospital. The only acceptable consent form is the one attached at the end of this protocol, and has been approved and amended by the MD Anderson Cancer Center (MDACC) Institutional Review Board (IRB)
- Patients must have Karnofsky performance status (KPS) \>= 60
- Patients must be able to obtain an MRI scan with gadolinium contrast
- Female patients of childbearing age must not be pregnant as determined with a serum beta human chorionic gonadotropin (HCG) no greater than 14 days prior to study registration, or breastfeeding. (The exclusion is made because gadolinium may be teratogenic in pregnancy). Female patients who consent to participate in the study will need to use contraceptive methods for the duration of the study
Exclusion
Key Trial Info
Start Date :
April 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 2 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04771806
Start Date
April 1 2019
End Date
February 2 2027
Last Update
September 9 2025
Active Locations (1)
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1
M D Anderson Cancer Center
Houston, Texas, United States, 77030