Status:
COMPLETED
Impact of Fish Oil Dose on Tissue Content and Function
Lead Sponsor:
University of Stirling
Collaborating Sponsors:
Danone Nutricia Research
Conditions:
Aging
Sarcopenia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this 5-month study, we will track the incorporation and washout of n-3 PUFA into different tissues following two different dosing strategies in healthy young and older volunteers. All groups will b...
Detailed Description
Skeletal muscle is crucial for health and accounts for approximately 40% of total body mass. A loss of skeletal muscle mass is seen in the process of ageing, with reductions between 0.2%-0.5% of muscl...
Eligibility Criteria
Inclusion
- Provide valid informed consent prior to any study procedure
- Males and females 18-35 years of age or 60+ years of age
- BMI between 18-29 kg/m2
- Free of musculoskeletal injuries
- Willing to avoid alcohol in the 48-h period prior to the visits
- Willing to sustain their current diet and lifestyle and not to make conscious changes for the duration of the study
- An omega-3 status of less than 20% seen in whole blood taken during the screening visit.
- Willing to sustain current use of supplementation/anti-depressants or other medication not interfering with the study results.
- Women: not currently pregnant, not intending to become pregnant in the coming 5 months or lactating.
- Women: willing to maintain current use of contraceptives or post-menopausal supplementation if any for the duration of the study.
- Not allergic to fish, shellfish, seaweed, iodine, anesthetics, nickel or chrome.
Exclusion
- Smoker
- Adherence to a strict vegan/vegetarian diet
- Treatment for cardiovascular diseases or blood pressure \>140/90 mmHg
- Any diseases or medication that cause fat malabsorption (intestine issues such as celiac disease, Crohn's disease,chronic pancreatitis, or cystic fibrosis; liver and biliary disease, diarrhoea, steatorrhea)
- Diabetes or other (metabolic) disease that induce muscle wasting
- Surgery in prior 6 months
- Currently being on FO supplementation
- Current participation in another clinical trial, or in a trial within the past month
- For women: pregnant, intention to get pregnant during the course of the study or lactating
Key Trial Info
Start Date :
November 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 15 2023
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT04772040
Start Date
November 1 2021
End Date
June 15 2023
Last Update
December 4 2023
Active Locations (1)
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1
University of Stirling
Stirling, Stirlingshire, United Kingdom, FK9 4LA