Status:

COMPLETED

Perioperative Immune Function and Clinical Complications in Pancreaduodenectomy

Lead Sponsor:

Rigshospitalet, Denmark

Conditions:

Pancreas Cancer

Eligibility:

All Genders

18+ years

Brief Summary

Perioperative immunologic signatures can predict the risk of postoperative complications. The results will be puplished as two smanuscripts. The manuscript will focus on preoperative immunologisk dat...

Detailed Description

OBJECTIVE Establish evidence for perioperative immunologic risk stratification of patient's risk for clinically postoperative inflammatory complications as a basis for future mechanism-based intervent...

Eligibility Criteria

Inclusion

  • Scheduled for PD on the suspicion of pancreatic cancer
  • Patients able to follow standardised surgical procedure including TIVA anaesthesia with epidural

Exclusion

  • Bilirubin \>100 µmol/ltr
  • Patients receiving immunomodulating treatment 1 month properatively and/or autoimmune diseases and patients non-cenacerous cystic lessions
  • Patients scheduled for simultaneous procedures on major arterial blood vessels, and/or adjacent organs (spleen, liver)
  • Inoperable patients, for instance, due to carcinosis, circulatory/ventilatory instability hindering procedure completion and/or concomitant surgery on major arterial blood vessels, spleen, or liver, are excluded post-inclusion and will not be part of the primary analysis
  • ongoing treatment with glucocortocoid, anti-tnf-alpha etc.
  • patients diagnosed with rheumatological diseases, IBD or chronic infection (eg. HIV)

Key Trial Info

Start Date :

February 1 2021

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

January 7 2024

Estimated Enrollment :

48 Patients enrolled

Trial Details

Trial ID

NCT04774198

Start Date

February 1 2021

End Date

January 7 2024

Last Update

April 6 2025

Active Locations (1)

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Page 1 of 1 (1 locations)

1

Rigshospitalet

Copenhagen, Denmark, 2100