Status:
COMPLETED
BRAF V600-mutated Lung Carcinoma Treated With the Combination of Dabrafenib-trametinib: a Retrospective Evaluation
Lead Sponsor:
Intergroupe Francophone de Cancerologie Thoracique
Collaborating Sponsors:
Novartis
Conditions:
Non Small Cell Lung Cancer
BRAF V600 Mutation
Eligibility:
All Genders
18+ years
Brief Summary
BLaDE cohort will evaluate overall survival (OS), real world progression-free survival (PFS), best response and duration of treatment in patients with advanced, metastatic Non-Small Cell Lung Cancer (...
Detailed Description
The braf gene (V Raf murine sarcoma viral oncogene homolog, long arm of chromosome 7q3) codes for a protein (serine / threonine kinase) which regulates the signaling pathway RAS - RAF - MEK - ERK play...
Eligibility Criteria
Inclusion
- Patients with histologically or cytologically confirmed extensive stage NSCLC
- Presence of BRAF V 600 E or non E mutation diagnosed on tumor sample and/or on liquid biopsy (co mutations allowed) between 01/01/2016 and 31/12/2019
- Patients who received at least one dose of treatment with dabrafenib-trametinib combination (whatever the treatment line)
- NSCLC BRAF V600 patients who have not received the dabrafenib-trametinib combination will be included for the collection of clinical and demographic data, treatments received and OS
- Patients who were informed about the study and do not refused for their data to be collected and used
- Age \> 18 years
Exclusion
- Patients harboring a non V600 BRAF mutation
- Patients enrolled in a clinical trial assessing treatment with dabrafenib-trametinib combination
- Explicit refusal by the patient to collect his or her data
- Patients under curatorship or guardianship
- Unable to obtain data collection
Key Trial Info
Start Date :
March 8 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
163 Patients enrolled
Trial Details
Trial ID
NCT04775095
Start Date
March 8 2021
End Date
December 31 2021
Last Update
January 6 2023
Active Locations (2)
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1
Créteil - CHI
Créteil, France
2
Lyon - CRLCC
Lyon, France