Status:
COMPLETED
Radiotherapy to the Primary in Metastatic Non-small Cell Lung Cancer Patients
Lead Sponsor:
Menoufia University
Conditions:
Non-Small Cell Carcinoma of Lung, TNM Stage 4
Radiation Therapy
Eligibility:
All Genders
Phase:
PHASE3
Brief Summary
study the effect of radiotherapy to the primary lesion after first line systemic therapy in metastatic non-small cell lung cancer patients.
Detailed Description
Metastatic non-small cell lung cancer patients after receiving their first line systemic therapy according to their genetic mutation will be randomized to follow up versus radiotherapy to the primary ...
Eligibility Criteria
Inclusion
- Confirmed histological diagnosis of NSCLC.
- Stage IV disease.
- Patients with P.S ≤ 2.
- finished at least 4 cycles of platinum-based doublet chemotherapy if patient has no diver mutation, or at least 3 months of anti-EGFR, Anti-ALK according to their driver mutation with SD, PR or CR.
Exclusion
- History of prior irradiation to the lung.
- residual Malignant pleural or pericardial effusion at randomization time.
- History of prior malignant tumor likely to interfere with the treatment protocol.
- Severe comorbidities as measured by morbidity index.
- Disease progression on first line systemic therapy.
Key Trial Info
Start Date :
September 25 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 25 2023
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT04776083
Start Date
September 25 2020
End Date
November 25 2023
Last Update
September 19 2024
Active Locations (1)
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1
Medicine
Shibīn al Kawm, Menoufia, Egypt, 32511