Status:
UNKNOWN
Potential for Inhaled Nitric Oxide and Ventilation-Perfusion Mismatch by Electrical Impedance Tomography in the ARDS Patients With Lung Recruitment
Lead Sponsor:
Far Eastern Memorial Hospital
Conditions:
Nitric Oxide
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
20-99 years
Phase:
NA
Brief Summary
In the recent years, the treatment of Acute Respiratory Distress Syndrome has been proved that lung recruitment re-opens the non-ventilated alveolar to improve ventilation, and inhaled Nitric Oxide di...
Detailed Description
Normally, pulmonary arteries in areas of alveolar hypoxia will constrict as a physiologic response to preserve ventilation/perfusion (V¬/Q¬) matching. However, in ARDS, this normal vasoconstrictive re...
Eligibility Criteria
Inclusion
- Moderate to severe ARDS patient on mechanical ventilation in MICU. (P/F≦ 200 with PEEP ≥ 5cmH20) (PEEP greater than or equal to 5 cm H2O and Berlin criteria for ARDS)
Exclusion
- Hemodynamic instability or severe COPD, pulmonary embolism
- Acute brain injury, seizure attack, AMI, AIDS, severe arrhythmia
- On pacemaker
- Pregnant
- Thoracic trauma or burn injury
- Pneumothorax
Key Trial Info
Start Date :
April 29 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04776408
Start Date
April 29 2022
End Date
December 31 2024
Last Update
January 31 2023
Active Locations (1)
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1
Far Eastern Memorial Hospital
Taipei County, Banqiao Dist, Taiwan, 22060