Status:
WITHDRAWN
Multimodality MRI and Liquid Biopsy in GBM
Lead Sponsor:
Abramson Cancer Center at Penn Medicine
Conditions:
Glioblastoma Multiforme
Brain Tumor, Adult: Glioblastoma
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Patients with a new diagnosis of high-grade glioma based on MRI, who are considered surgical candidates determined by neurosurgeons or patients with recurrent glioblastoma with the initial diagnosis o...
Detailed Description
This is a pilot study in subjects with a new diagnosis of high-grade glioma based on classic MRI appearance who are considered surgical candidates and patients with histologically proven diagnosis of ...
Eligibility Criteria
Inclusion
- Participants will be ≥ 18 years of age
- Patients with new diagnosis of high grade glioma based on MRI, who are considered surgical candidates determined by neurosurgeons or recurrent glioblastoma with the initial diagnosis of glioblastoma (histologic or molecular proof) and recommended for clinically surgical resection
- Life expectancy of greater than 3 months in the opinion of an investigator or treating physician.
- Karnofsky performance status ≥ 60
Exclusion
- Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
- Females who are pregnant or breast feeding at the time of screening will not be eligible for this study; pregnancy status will be confirmed verbally prior to participating in any study procedures.
- Any current medical condition, illness, or disorder as assessed by medical record review and/or self-reported that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study
- Contraindications to MRI or use of ferumoxytol or gadolinium contrast
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 22 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04776980
Start Date
June 1 2022
End Date
June 22 2022
Last Update
September 16 2022
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104