Status:
WITHDRAWN
Use of a Rapid Diagnostic Test for Antibiotic De-escalation in Severe Community Acquired Pneumonia
Lead Sponsor:
Northwestern University
Conditions:
Community-acquired Pneumonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to conduct an open-label step-wedge pilot clinical trial to compare an antibiotic strategy based on routine use of a novel rapid diagnostic test to usual care in criticall...
Detailed Description
The purpose of this study is to conduct an open-label step-wedge pilot clinical trial to compare an antibiotic strategy based on routine use of a novel rapid diagnostic test to usual care in criticall...
Eligibility Criteria
Inclusion
- Adults aged 18 years and older with known or suspected community-acquired pneumonia who are admitted to the MICU Service
- Meets one of the following:
- Have or plan to obtain a bronchoalveolar lavage (BAL)
- Have or plan to obtain a quantitative endotracheal aspirate sample
- Have already produced a high-quality sputum sample if not intubated
- Primary MICU attending and fellow willing to base antibiotic therapy on results of RDT
Exclusion
- Subjects with confirmed extrapulmonary infection requiring antibiotics outside the usual treatment for SCAP, with the exception of suspected uncomplicated urinary tract infection
- Neutropenic fever, defined as absolute neutrophil count \<1000/mm3 and absence of infiltrate on available chest imaging
- Chronic airway infection, defined as cystic fibrosis, lung transplant, or non-CF bronchiectasis
- Patient/surrogate refusal
- Inability to perform BAL, NBBAL, quantitative ETA, or produce a high-quality sputum sample prior to 48 hours from hospital admission
Key Trial Info
Start Date :
January 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 15 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04781829
Start Date
January 15 2020
End Date
February 15 2021
Last Update
March 4 2021
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