Status:
ACTIVE_NOT_RECRUITING
ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research Program
Lead Sponsor:
The Hospital for Sick Children
Collaborating Sponsors:
Children's Hospital of Philadelphia
University of Alabama at Birmingham
Conditions:
Pediatric Multiple Sclerosis
Eligibility:
All Genders
11-21 years
Phase:
NA
Brief Summary
The investigators have previously shown that youth with MS are very inactive, and that vigorous physical activity is associated with higher levels of well-being and lower MS disease activity in youth....
Detailed Description
Youth with MS have highly active disease and report high levels of fatigue and depression. As MS is a lifetime diagnosis, amelioration of these outcomes may have a sustained and important effect on th...
Eligibility Criteria
Inclusion
- Youth 11-21 years of age;
- MS diagnosis or clinically isolated syndrome, as per revised McDonald diagnostic criteria and International Pediatric MS Study Group criteria prior to the age of 18;
- Participating in less than three hours of structured physical activity per week.
Exclusion
- Have non-specific white matter abnormalities and metabolic or infectious etiologies for white matter abnormalities;
- Do not speak and read English at a level needed to complete the questionnaires (4th grade level);
- Have significant motor disability, classified as an Expanded Disability Status Scale (EDSS) ≥4;
- Are at increased risk of cardiac or other complications of exercise testing (e.g. cardiac disease, diabetes), as determined by the pediatric neurologist or physician.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT04782466
Start Date
December 1 2020
End Date
September 1 2025
Last Update
September 23 2025
Active Locations (3)
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1
The University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
2
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
3
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8