Status:
ACTIVE_NOT_RECRUITING
Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula
Lead Sponsor:
Vanderbilt University Medical Center
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Intubation
Cardiovascular Surgical Procedure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The iCAN trial is a pragmatic randomized controlled trial that aims to test the hypothesis that HFNC versus usual care oxygenation strategies applied immediately after initial extubation after cardiac...
Detailed Description
HFNC may be employed as a strategy to facilitate early extubation and prevent reintubation of patients following cardiac surgery. HFNC is routinely employed by providers in the cardiovascular intensiv...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age ≥18 years
- Undergoing cardiac surgery, defined as a documented surgical service of "cardiac surgery" in the electronic health record, performed in the main operating rooms at Vanderbilt University Medical Center
- Admitted to the cardiovascular intensive care unit postoperatively with an endotracheal tube in place and mechanically ventilated
- Surgery duration (documented time between "Anesthesia start" and "Anesthesia stop" in the EHR) of at least 180 minutes
- Received an order to be extubated by a treating provider o Patients who meet all other criteria but do not receive an order to extubate will be randomized but not enrolled
- Exclusion Criteria
- • Patient does not meet inclusion criteria
Exclusion
Key Trial Info
Start Date :
November 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
3400 Patients enrolled
Trial Details
Trial ID
NCT04782817
Start Date
November 1 2021
End Date
March 1 2026
Last Update
December 15 2025
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212