Status:
COMPLETED
Characterizing Inflammatory Profiles and Suicidal Behavior in Adolescents
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
American Foundation for Suicide Prevention
Conditions:
Suicide and Depression
Eligibility:
All Genders
12-18 years
Brief Summary
Despite increasing suicide rates in adolescents, there remains a paucity of approaches to use to prevent re-attempts. Any hope for breaking the code to prevent youth suicide lies in understanding biol...
Detailed Description
The purpose of this study is to map inflammatory dysfunction to suicidal behavior and establish a reliable immune signature of suicide risk that can 1) guide future research into fundamental pathophys...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Study participants must:
- Be adolescents (aged 12-18 years);
- Have the ability to speak, read, and understand English. The parent(s) or legal guardians of minors must also speak, read and understand English;
- Be willing to provide consent/assent. Consent will be provided by parents/LAR/guardian for youth under age 18 or by young adult participant, aged 18. Youth, aged 8-17, must be willing to provide assent;
- Have the ability to complete clinical evaluations and self-report measures;
- Meet criteria for one of these three groups:
- Adolescent with suicidal behaviors, defined as having a recent (within 3 months) suicide attempt or suicidal ideation warranting urgent evaluation;
- Adolescents at risk for mood disorders, defined by either personal history of anxiety disorder or substance use disorder or a history of trauma, or a first degree relative with a history of a mood disorder or suicidal history;
- Healthy adolescents with no lifetime history of any psychiatric or substance use disorders or a history of trauma. Additionally, no first-degree family member with a history of a mood disorder or suicidal history..
- Exclusion Criteria
- Study participants must not:
- Have current poorly controlled asthma, acute/chronic infection or other medical condition(s) that may affect immune marker levels;
- Have a current medication (e.g., corticosteroids) that may affect immune marker levels of reactivity;
- Have any condition for which, in the opinion of the investigator or designee, study participation would not be in their best interest (including but not limited to cognitive impairment, unstable general medical condition, intoxication, active psychosis) or that could prevent, limit, or confound the protocol-specified assessments;
- Be unable to provide a stable home address and contact information
Exclusion
Key Trial Info
Start Date :
April 28 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 31 2025
Estimated Enrollment :
225 Patients enrolled
Trial Details
Trial ID
NCT04783506
Start Date
April 28 2021
End Date
August 31 2025
Last Update
December 19 2025
Active Locations (1)
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1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75235