Status:
COMPLETED
The Effectiveness of Different Doses of Hyaluronic Acid Injections in Knee Osteoarthritis.
Lead Sponsor:
Istanbul University
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
The aim of this prospective, randomized, controlled multi-centre study is to compare the effectiveness and safety of three and five injections of standard linear hyaluronic acid (HA) versus single HA ...
Detailed Description
Osteoarthritis (OA) is the most common form of chronic joint disease. A treatment option for patients diagnosed with knee osteoarthritis is intra-articular hyaluronic acid therapy. In this prospective...
Eligibility Criteria
Inclusion
- Unilateral or bilateral symptomatic knee pain for at least three months
- Presence of Kellgren-Lawrence stage 2-3 osteoarthritis on current anterior-posterior knee radiographs
- Functional ambulation scale stage 4-5
- Being able to attend injection and control examinations
Exclusion
- Intra-articular knee injection within the last six months
- History of severe trauma to the knee within the past six months
- Concomitant severe meniscus or ligament injury, surgery applied to the knee area
- Presence of severe effusion, inflammatory joint disease, infection, hematological and oncological disease in the knee.
- Having a bleeding disorder and / or using warfarin
- Kellgren-Lawrence stage 1 or stage 4 osteoarthritis on current anterior-posterior knee radiographs
- Presence of cardiac or systemic disease that may affect exercise
- The presence of neurological disease and psychiatric disease such as Parkinson's disease, stroke history that may affect balance
- Body Mass Index ≥35 kg / m²
- Allergy to hyaluranic acid products
Key Trial Info
Start Date :
March 10 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 7 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04786613
Start Date
March 10 2021
End Date
November 7 2021
Last Update
October 18 2022
Active Locations (1)
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1
Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation
Istanbul, Fatih, Turkey (Türkiye), 34034