Status:
COMPLETED
The Effects of Low Energy Availability and High Impact Jumping on Markers of Bone (re)Modelling in Females
Lead Sponsor:
Loughborough University
Conditions:
Bone Resorption
Bone Atrophy
Eligibility:
FEMALE
18-35 years
Phase:
NA
Brief Summary
Osteoporosis is worldwide health epidemic categorized by poor bone health, primarily diagnosed by low bone mineral density, and costs healthcare systems billions every year. Athletes and exercising pe...
Detailed Description
Participants will complete two four-day experimental conditions within the first seven days of two separate menstrual cycles. These will be preceded by a four-day baseline assessment period. There are...
Eligibility Criteria
Inclusion
- To take part in this study, the following inclusion criteria must be met:
- Menstrual cycles that are between 21 - 35 days in length for at least the previous three cycles
- Regular length of menstrual cycle (less than six days difference between cycles) for at least the previous three cycles
- Body mass index between 18.5 - 30 kg.m squared
- Weight stable for the past three months and not currently dieting
- Participants will not be able to take part in this study if any of the following exclusion criteria are met:
- Smoker
- Pregnant
- Vegan
- Have used hormonal contraception at any point within the previous three months
- Regularly engage in \>3 vigorous, or \>5 moderate, exercise sessions a week
- Compete regularly in a high or multi-directional impact sport at national level or higher
- Have sustained a bone injury within the previous twelve months
- Have sustained any injury within the past six months that restricted their ability to exercise
- Taken hormone replacement therapy (HRT) at any point during the past three months
- Have been previously diagnosed with an eating disorder
- Have taken any medications (other than vitamin or mineral supplements) known to effect bone metabolism within the previous three months (e.g. glucocorticoids, anticonvulsants or anabolic steroids)
- Have previously been diagnosed with a medical condition known to impact bone health (e.g. hypothyroidism, hyperthyroidism, diabetes mellitus, hypercortisolism and renal or gastrointestinal disease)
- Have previously been diagnosed with a pathology known to impact menstrual function (e.g. primary ovarian insufficiency, hyperprolactinemia, thyroid dysfunction, polycystic ovarian syndrome and any other conditions of androgen excess)
Exclusion
Key Trial Info
Start Date :
November 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2022
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT04790019
Start Date
November 1 2020
End Date
June 30 2022
Last Update
February 14 2023
Active Locations (1)
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1
Mark Hutson
Loughborough, Leicestershire, United Kingdom, LE11 3TU