Status:
COMPLETED
Pericoronary Fat Attenuation Index and High-risk Plaque in Patients With Acute Coronary Syndrome
Lead Sponsor:
RenJi Hospital
Conditions:
Acute Coronary Syndrome
Eligibility:
All Genders
18-75 years
Brief Summary
This study aimed to investigate the relationship between CCTA-based pericoronary inflammation and plaque features as well as local immune-inflammatory biomarkers in ACS patients. It is hypothesized th...
Detailed Description
The pericoronary fat attenuation index (FAI), which capture by standard coronary computed tomography angiography (CCTA), has emerged as a novel imaging biomarker of coronary inflammation. This study a...
Eligibility Criteria
Inclusion
- non-ST-elevation ACS (non-ST-elevation myocardial infarction or unstable angina) age from 18 to 75 years which underwent CCTA were prospectively enrolled in this study.
Exclusion
- Patients needed an immediate (\<2 h) or early invasive strategy (\<24 h) according to guidelines were excluded: including those presented with haemodynamic instability or cardiogenic shock, life-threatening arrhythmia or cardiac arrest, mechanical complication, acute heart failure, dynamic ST or T wave changes, GRACE score \>140;
- Subjects with previous history of coronary artery bypass graft surgery or PCI, immune system disorder, tumor, acute/chronic infection, atrial fibrillation, end-stage renal failure, iodine-containing contrast allergy were also excluded.
- After CCTA performance, we also exclude patients with no significant (≥50%) stenosis on major epicardial vessels and those refused subsequent angiography.
- Participants with total obstruction on major epicardial vessel, or insufficient image quality for FAI and QangioCT analysis, as well as lack of blood sample were excluded.
Key Trial Info
Start Date :
January 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2020
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT04792047
Start Date
January 1 2019
End Date
January 31 2020
Last Update
March 10 2021
Active Locations (1)
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1
Cardiology, Ren Ji Hospital
Shanghai, China