Status:
UNKNOWN
Cognition and the Immunology of Postoperative Outcomes
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Cognitive Impairment
Frail Elderly Syndrome
Eligibility:
All Genders
65+ years
Brief Summary
This research will test the hypothesis that immune system disequilibrium / dysfunction explains why preoperative cognitive impairment is a strong predictor of postoperative morbidity in older surgical...
Detailed Description
This project is designed as a prospective, single-center observational study. The cohort will consist of 600 consenting subjects ≥ 65 years of age that agree to have a study investigator speak with th...
Eligibility Criteria
Inclusion
- Patients ≥ 65 years of age
- American Society of Anesthesiologists (ASA) physical status of I-III
- Scheduled for elective spine surgery.
Exclusion
- History of stroke (not including transient ischemic attacks, or TIAs)
- History of brain tumor
- History of autoimmune disorders
- Medications likely to significantly impact inflammation (e.g. steroids)
- Current infection
- Uncorrected vision or hearing impairment
- limited use of the dominant hand (limited ability to draw)
- inability to speak, read, or understand English.
Key Trial Info
Start Date :
September 6 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 31 2025
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT04792983
Start Date
September 6 2019
End Date
July 31 2025
Last Update
March 12 2021
Active Locations (1)
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1
Brigham & Women's Hospital
Boston, Massachusetts, United States, 02115