Status:
RECRUITING
Regional Phenotyping of CF and Non-CF Bronchiectasis
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Conditions:
Cystic Fibrosis
Non-CF Bronchiectasis
Eligibility:
All Genders
5-100 years
Brief Summary
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severi...
Detailed Description
Specific Aim 1: Validate functional imaging markers in CF patients with normal spirometry but abnormal ventilation. The Investigators hypothesize imaging phenotype can predict lung function decline, e...
Eligibility Criteria
Inclusion
- CF Patients: Diagnosis of CF based on sweat chloride \>60 mMol/l
- Presence of two disease causing CFTR mutations, or end organ manifestations of disease.
- Age minimum 5 years.
- Care provided by the CCHMC CF Care Center or other regional CF Care Centers if required to achieve recruitment goals.
Exclusion
- Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
- Pregnancy or lactation.
- Inclusion Criteria of Healthy Subjects:
- Subjects 5 years of age and older with no known history of cardiopulmonary disease.
- Exclusion Criteria of Healthy Subjects:
- Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
- Pregnancy or lactation.
Key Trial Info
Start Date :
February 8 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04793867
Start Date
February 8 2021
End Date
March 31 2027
Last Update
February 20 2025
Active Locations (1)
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1
Penny New
Cincinnati, Ohio, United States, 45229