Status:
COMPLETED
Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers
Lead Sponsor:
Centre Hospitalier Universitaire, Amiens
Conditions:
Optical Coherence Tomography
Optical Coherence Tomography Angiography
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Alzheimer disease is hard, long and expensive to diagnose. In order to help the clinician, a new biomarker in Alzheimer disease seems to be very useful. The retina, as a window of the brain, could off...
Eligibility Criteria
Inclusion
- Patients having a consultation in the Research and Resources Memory Center of Amiens (RRMC) ,
- patients registered in the Alzheimer National Bank and having an Alzheimer Disease based on NIA-AA (McKahnn2011)and IWG2 (Dubois et al, 2014) criteria or, having a Lewy body disease based on revised criteria of McKeith et al 2020
- patients having a complete neuropsychological evaluation including a visual inspection time.
- patients having a MMSE ≥ 18/30 so as to ensure a good homogeneity of the group and to have an adequate ocular exam's quality.
- patients having an available MRI in the CHU's database including a 3DT1 sequence
- patients having a visual acuity better than 5/10, spherical refraction of +/- 5D, an astigmatism \< 3D and an applanation IOP \<22mmHg
Exclusion
- Any other neurocognitive disorder
- Any other optical neuropathy including glaucoma
- All kind of retinal disease (diabetic retinopathy, age-related macular degeneration…)
- Diabetes mellitus
- Uncontrolled hypertension blood pressure
- Any ophthalmological conditions interfering with a good ocular examination or OCT quality (cataract, corneal opacity..)
- Severe dementia preventing a good ophthalmological examination
- Not consenting patient
- Patient with guardianship or curatorship having symptoms preventing a good ophthalmological examination (agitation, unstable ocular fixation)
Key Trial Info
Start Date :
January 13 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2025
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT04794634
Start Date
January 13 2021
End Date
December 1 2025
Last Update
December 8 2025
Active Locations (1)
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1
CHU Amiens
Amiens, France, 80480