Status:
COMPLETED
Resistance Training and Clinical Status in Patients With Post Discharge Symptoms After Covid-19
Lead Sponsor:
Universidad Pública de Navarra
Collaborating Sponsors:
Fundacion Miguel Servet
Complejo Hospitalario de Navarra
Conditions:
Covid19
SARS-CoV2
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
COVID-19 survivors commonly exhibit a marked extra-respiratory complication affecting the cardiac (arrhythmias and myocardial injury), renal (acute kidney injury), gastrointestinal, nervous (neuropath...
Detailed Description
100 patients will be recruited and undergo baseline testing, including examination, immune systems, biochemistry markers, ECG, DXA, metabolic/respiratory function, VO2max, muscular fitness, lipidomic/...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- SARS-CoV-2 diagnosed using real-time reverse transcriptase polymerase chain reaction (PCR) tests or positive for SARS-CoV-2 virus antigen \>90 days before randomization.
- Still present a chronic symptomatic phase lasting \>90 days since debut of symptoms.
- Have not been hospitalized.
- There is no evidence on clinical records of pneumonia or any other organ failure related to SARS-CoV-2.
- Capable and willing to provide an informed consent.
Exclusion
- Pregnancy or breast-feeding.
- Present atrial fibrillation.
- Diagnosed with acute myocarditis.
- Health conditions that prevent participating in the exercise intervention
- Patients who cannot undergo VO2max (e.g. acute heart attack or unstable angina, aortic stenosis, acute endocarditis / pericarditis, uncontrolled high blood pressure, acute thromboembolism, severe heart failure, respiratory failure and uncontrolled acute decompensated diabetes mellitus or low blood sugar).
- Treatment with IL-6 receptor antagonists (tocilizumab, kevzara) within the last month due to drug interference with the cardiopulmonary exercise adaptations.
Key Trial Info
Start Date :
March 8 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 18 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04797871
Start Date
March 8 2021
End Date
September 18 2022
Last Update
November 2 2022
Active Locations (1)
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1
Robinson Ramírez-Vélez, Ph.D
Pamplona, Spain, 31001