Status:
RECRUITING
Systems Biology of Early Atopy
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsors:
Consortium for Food Allergy Research
Rho Federal Systems Division, Inc.
Conditions:
Allergic Diseases
Food Allergy
Eligibility:
All Genders
Brief Summary
The goal of this study is to establish a birth cohort that collects prenatal and early life biosamples and environmental samples and rigorously phenotypes young children for food allergy and Atopic De...
Detailed Description
This is a prospective cohort study in which pregnant women (at any stage of pregnancy), the offspring's biologic father, and the offspring will be enrolled at study sites and the offspring will be obs...
Eligibility Criteria
Inclusion
- Pregnant Women-
- Pregnant women who meet all of the following criteria are eligible for enrollment as study participants:
- Age 18 years or older
- Able to understand the oral and written instructions associated with study visits and procedures and provide informed consent
- Pregnant at any stage
- Planning to give birth at a study-site designated center
- Agrees to enroll offspring into the study at birth
- In the case of multiple gestation, agrees to enroll only one child who will be selected by randomized birth order
- Biological Fathers-
- Biological fathers who meet all of the following criteria are eligible for enrollment as study participants:
- Age 18 years or older
- Able to understand the oral and written instructions associated with study visits and procedures and provide informed consent
Exclusion
- Pregnant Women-
- Pregnant women who meet any of these criteria are not eligible for enrollment:
- Inability or unwillingness to comply with study protocol
- Serious pregnancy complication (in the judgement of the investigator) prior to enrollment
- Fetus has a major chromosomal anomaly
- Plans to move and would not be available for in-person visits at a study site
- Plans to give up her child for adoption at birth
- Pregnancy is the result of an egg donation
- Infants-
- Infants who meet any of these criteria are not eligible for enrollment:
- Delivered earlier than 34 weeks of gestation
- Sibling already enrolled
- Born with a significant birth defect or medical condition, and in the judgment of the investigators, participation is not in the infant's best interest
- Biological Father-
- 1\. Biological fathers who are unable or unwilling to comply with the study protocol as it pertains to the biological father's participation are not eligible for enrollment
- ---Note Regarding Legal Guardians who are not the Biological Parents:
- At screening for enrollment of either the mother or the child, if the biological mother intends to give the infant up for adoption, neither the mother nor the child are eligible for enrollment
- If the biological mother gives up legal guardianship of the child during the child's follow-up period, the child may remain enrolled as long as the new legal guardian:
- Agrees to meet the child's study requirements, and
- Provides written informed consent for the child's continued participation.
- Throughout the protocol where it refers to the mother, father, or parent answering questionnaires about the child or collecting samples from the child and the child's primary home, the legal guardian who provides consent for the child's participation may complete those procedures
Key Trial Info
Start Date :
March 18 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2032
Estimated Enrollment :
2500 Patients enrolled
Trial Details
Trial ID
NCT04798079
Start Date
March 18 2021
End Date
March 1 2032
Last Update
May 16 2025
Active Locations (12)
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1
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202
2
Sean N. Parker Center for Allergy & Asthma Research at Stanford University
Stanford, California, United States, 94040
3
National Jewish Health
Denver, Colorado, United States, 80206
4
Johns Hopkins Children's Center, Department of Allergy & Immunology
Baltimore, Maryland, United States, 21287