Status:
ACTIVE_NOT_RECRUITING
Visual Rehabilitation After Occipital Stroke
Lead Sponsor:
University of Rochester
Collaborating Sponsors:
National Eye Institute (NEI)
Conditions:
Stroke, Ischemic
Quadrantanopia
Eligibility:
All Genders
21-75 years
Phase:
NA
Brief Summary
This research aims to examine changes in plastic potential of the visual system with time from stroke affecting primary visual cortex. We will measure structural and mechanistic aspects of progressive...
Eligibility Criteria
Inclusion
- Residents of US and Canada
- MRI and/or CT scans showing evidence of one-sided / unilateral stroke or stroke-like damage to the primary visual cortex or its immediate afferent white matter sustained less than 6-months prior to enrollment
- Reliable visual field defects in both eyes as measured by Humphrey, Macular Integrity Assessment (MAIA), Goldmann, and/or equivalent perimetry. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.
- Ability to fixate on visual targets reliably for 1000ms (as demonstrated by visual fields, and verified in study participation)
- Willing and safely able to undergo magnetic resonance imaging (MRI) scanning
- Willing, able, and competent to provide informed consent
- Fluent in written and spoken English
- Cognitively able, responsible, and willing to complete daily visual training independently at home for several months.
Exclusion
- Past or present ocular disease interfering with vision
- Best corrected visual acuity worse than 20/40 in either eye
- Presence of damage to the dorsal Lateral Geniculate Nucleus, as shown on MRI/CT scans
- Diffuse, whole brain degenerative processes
- Brain damage deemed by study staff to potentially interfere with training ability or outcome measures
- History of traumatic brain injury
- Documented history of drug/alcohol abuse
- Currently use of neuroactive medications which would impact training, as determined by PI
- Cognitive or seizure disorders
- One-sided attentional neglect
- Inability to perform the visual training exercises as directed
Key Trial Info
Start Date :
July 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2028
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04798924
Start Date
July 19 2021
End Date
January 1 2028
Last Update
December 3 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Rochester
Rochester, New York, United States, 14642