Status:
UNKNOWN
Effect of LCZ696 on Urinary Microalbumin and Pulse Wave Velocity in Perimenopausal Patients With Hypertension
Lead Sponsor:
LanZhou University
Conditions:
Hypertension
Eligibility:
FEMALE
40-60 years
Phase:
NA
Brief Summary
To explore the efficacy of Sacubitril/Valsartan in the treatment of perimenopausal hypertensive patients, as well as the difference between the antihypertensive efficacy and valsartan, the therapeutic...
Detailed Description
A total of 264 cases of perimenopausal patients with essential hypertension who were admitted to Department of Cardiology, Second Hospital of Lanzhou University,from January, 2020 to March,2021 will b...
Eligibility Criteria
Inclusion
- Patients with essential hypertension（SBP\>140 and \<180 mmHg, and/or DBP\>90 and \<110 mmHg)）were diagnosed according to the hypertension diagnostic criteria of the Chinese Guidelines for Hypertension (2018 Revised Edition)；
- Female aged 45-55 years old and meeting the perimenopausal criteria in the STRAE+10;
- No other complications, no treatment or ongoing antihypertensive therapy (SBP ≥140mmHg or Diastolic BP ≥90mmHg)；
- Agree to participate in the study and sign the informed consent；
Exclusion
- Secondary hypertension；
- History of angioedema；
- Heart failure NYHA grade III or above (excluding grade III)；
- Liver and kidney dysfunction (ALT or AST≥ three times the upper limit of normal value, that is, ALT≥120U/L,AST≥120U/L, creatinine clearance \< 30ml/min);
- Hyperkalemia (serum potassium ≥5.5mmol/L);
- Moderate or above anemia (HGB≤90g/L);
- Bilateral renal artery stenosis;
- History of stroke;
Key Trial Info
Start Date :
July 9 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 9 2021
Estimated Enrollment :
264 Patients enrolled
Trial Details
Trial ID
NCT04800081
Start Date
July 9 2020
End Date
July 9 2021
Last Update
March 16 2021
Active Locations (1)
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1
Department of Cardiology, Second Hospital of Lanzhou University
Lanzhou, GuSu, China