Status:
COMPLETED
Brazilian Green Propolis Extract (EPP-AF) as an Adjunct Treatment for Hospitalized COVID-19 Patients (BeeCovid2)
Lead Sponsor:
D'Or Institute for Research and Education
Collaborating Sponsors:
Apis Flora Industrial e Comercial Ltda
Conditions:
Covid19
Inflammation
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes challenging immune and inflammatory phenomena. Though various therapeutic possibilities have been tested against coronavirus disea...
Detailed Description
To evaluate the efficacy and safety of oral propolis as an adjunct treatment for SARS-CoV-2 infection, we designed a randomized, double-blind, placebo-controlled trial (Bee-Covid2) (The Use of Brazili...
Eligibility Criteria
Inclusion
- Older than 18 years;
- Diagnosis of coronavirus infection confirmed by polymerase chain reaction - reverse transcriptase testing;
- Symptoms started within 14 days of the randomization date
Exclusion
- Pregnant or lactating women;
- Known hypersensitivity to propolis;
- Propolis use less than 30 days from the randomization date;
- Active cancer;
- Human immunodeficiency virus carriers;
- Patients undergoing transplantation of solid organs or bone marrow or who were using immunosuppressive medications;
- Bacterial infection at randomization, sepsis or septic shock related to bacterial infection at randomization;
- Impossibility of using the medication orally or by nasoenteral tube;
- Known hepatic failure or advanced heart failure (New York Heart Association \[NYHA\] class III or IV).
- End Stage Renal Disease (ESRD).
Key Trial Info
Start Date :
April 12 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 30 2021
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04800224
Start Date
April 12 2021
End Date
July 30 2021
Last Update
May 13 2022
Active Locations (1)
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1
Hospital Sao Rafael
Salvador, Estado de Bahia, Brazil, 41820340