Status:
UNKNOWN
Salivary C- Reactive Protein, Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Diagnostic Markers for Neonatal Sepsis
Lead Sponsor:
Cairo University
Conditions:
Neonatal Sepsis
Eligibility:
All Genders
1-28 years
Brief Summary
To evaluate reliability of salivary C-reactive protein ,mean platelet volume , neutrophil -lymphocyte ratio , and platelet lymphocyte ratio in diagnosis of neonatal sepsis
Eligibility Criteria
Inclusion
- \- Full term neonates of both genders from birth to the 28th day of life diagnosed with sepsis by history, clinical findings, laboratory findings, and blood culture. The clinical findings included the presence of three or more of the following:
- (1) temperature instability (hypothermia, hyperthermia) .
- (2) respiratory alterations (grunting, intercostal retractions, apnea, tachypnea, cyanosis) .
- (3) cardiovascular alterations (bradycardia, tachycardia, poor perfusion, hypotension) .
- (4) neurologic alterations (hypotonia, lethargy, seizures)
- (5) gastrointestinal alterations (feeding intolerance, abdominal distension). CRP values \>10 mg/L were considered to be positive.
Exclusion
- \- Preterm neonates .
- Neonates with CNS malformations, metabolic disorders, chromosomal abnormalities, intrauterine growth restriction, or birth asphyxia were excluded from the study
Key Trial Info
Start Date :
April 4 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 10 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04800445
Start Date
April 4 2020
End Date
January 10 2022
Last Update
August 9 2021
Active Locations (1)
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1
Faculty of medicine
Cairo, Almanyal, Egypt, 11562