Status:
ACTIVE_NOT_RECRUITING
SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial
Lead Sponsor:
Milton S. Hershey Medical Center
Collaborating Sponsors:
AXIOM Real Time Metrics
Analytica Ventures LLC
Conditions:
Covid19
SARS-CoV Infection
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
Adults (aged 18-65 years) recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® w...
Detailed Description
Investigators have demonstrated the in vitro viridical efficacy of both Listerine Antiseptic® and 1% dilute baby shampoo solution, a commonly used nasal rinse, against a SARS-CoV-2 surrogate and Meist...
Eligibility Criteria
Inclusion
- A first-time positive test for SARS-CoV-2 infection within 5 days of enrollment
- Adults who are ≥18 -65 years of age
- Currently in isolation
- Symptomatic or asymptomatic from SARS-CoV-2
Exclusion
- History of nasal or sinus surgery
- Non-English speaking
- Lack of electronic device (computer, mobile phone etc.) on which to access an app for study data collection.
- Adults that need inpatient care for COVID-19 or any of its complications.
- Adults that give a history of being unable to tolerate gargles or nasal washes.
- Adults who do not give informed consent for study participation.
- History of a Covid vaccine booster
- A history of use of nasal or oral washes after SARS-CoV-2 test sample collection.
- Prisoners
- Adults that give history of current pregnancy (NO KNOWN CONTRAINDICATION TO PREGNANCY)
- History of monoclonal antibody treatment
- History of or current molnupiravir treatment
Key Trial Info
Start Date :
October 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2026
Estimated Enrollment :
171 Patients enrolled
Trial Details
Trial ID
NCT04802408
Start Date
October 1 2021
End Date
May 30 2026
Last Update
October 28 2025
Active Locations (2)
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1
Penn State Health Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
2
Penn State
State College, Pennsylvania, United States, 16801