Status:
UNKNOWN
Omega-3 Unsaturated Fatty Acid Improves Cognitive Function in Patients With Depression
Lead Sponsor:
Guangzhou Psychiatric Hospital
Conditions:
Cognitive Impairment
Depression
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The aim of this study was to evaluate the effect of n-3pufas on cognitive function in patients with depression
Detailed Description
Depression is often accompanied by cognitive impairment. At present, there is no effective drug to improve the cognitive impairment in patients with depression, and the social function and quality of ...
Eligibility Criteria
Inclusion
- ① the patients met the diagnostic criteria of dsm-5 major depressive disorder; ② aged 18-55 years; ③ Hamilton Depression Scale score of 24 items ≥ 20 points; YMRS score \< 6 points; ④ the score of wms-ii spatial span (assessment of working memory) in MCCB tool was less than or equal to its mean half standard deviation; ⑤ antidepressant types had not been adjusted in recent 2 weeks; 6) right handedness; 7) primary school had no change in the types of antidepressants The patients or their family members are willing to participate in the study and sign the informed consent.
Exclusion
- ① Merge with any other mental disorder; ② Patients with history of brain organic disease or traumatic brain injury and physical diseases; ③ abusers of drugs, alcohol or other psychoactive substances; ④ pregnant, lactating women and postpartum women; ⑤ refractory depression; ⑥ severe suicide risk (c-ssrs assessment); ⑦ MECT treatment in recent three months; ③ continuous use of diazepam drugs in recent three months; Ⅸ long-term use of npufas in recent three months; ⑩ Long term use of anti-inflammatory drugs in the past three months.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2022
Estimated Enrollment :
288 Patients enrolled
Trial Details
Trial ID
NCT04803071
Start Date
October 1 2020
End Date
October 1 2022
Last Update
March 17 2021
Active Locations (1)
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1
Guangzhou Brain Hospital (Guangzhou Huiai Hospital)
Guanzhou, Guangdong, China, 510370