Status:
COMPLETED
Study of Pain Catastrophizing-2 (SPAC-2)
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
45-85 years
Phase:
NA
Brief Summary
This study experimentally manipulates pain catastrophizing in order to investigate the neural mechanisms by which pain catastrophizing influences the experience of pain in different ethnic groups amon...
Eligibility Criteria
Inclusion
- Symptomatic knee OA
Exclusion
- Younger than 45 years of age or older than 85 years of age
- Prosthetic knee replacement or other clinically significant surgery to the arthritic knee
- Uncontrolled hypertension (\>150/95)
- Heart disease including heart failure
- Peripheral neuropathy in which pain testing was contraindicated
- Systemic rheumatic disorders including rheumatoid arthritis, systemic lupus erythematosus, gout, and fibromyalgia
- Neurological diseases such as Parkinson's, multiple sclerosis, stroke with loss of sensory or motor function, or uncontrolled seizures
- Significantly greater pain in body sites other than in the knee
- Daily opioid use
- Hospitalization within the preceding year for psychiatric illness
- Currently pregnant or nursing/breastfeeding
Key Trial Info
Start Date :
October 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 12 2023
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT04805190
Start Date
October 15 2021
End Date
December 12 2023
Last Update
May 14 2024
Active Locations (1)
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1
UF Health at the University of Florida
Gainesville, Florida, United States, 32610