Status:
UNKNOWN
Decompensation of Cirrhosis and Iron Metabolism
Lead Sponsor:
Rennes University Hospital
Conditions:
Cirrhosis
Eligibility:
All Genders
18+ years
Brief Summary
Iron is a crucial metal whose metabolism is tightly regulated. Iron deficiency or iron overload are both deleterious at the cellular, organic and systemic levels. In line with the major role of the li...
Eligibility Criteria
Inclusion
- Age ≥ 18 years old.
- Diagnosis of cirrhosis, previously known or not, of any etiology, histologically proven or not.
- Hospitalization for acute on chronic liver failure:
- Ascites decompensation.
- Or spontaneous infection of the ascites fluid (defined as PNN \> 250/mm3 of ascites).
- Or digestive hemorrhage related to portal hypertension (digestive fibroscopy showing active bleeding or stigmas of recent bleeding from esophageal and/or gastric varices).
- Or hepatic encephalopathy (clinically defined +/- increase in ammonia and/or by electroencephalogram and classified in stages according to West-Haven).
- Or hepato-renal syndrome (HRS-AKI criteria, EASL 2018).
- Or bacterial infection (defined by a bacteremia identified by at least one blood culture and/or an infectious site authenticated on imaging).
- Or Acute Alcoholic Hepatitis (histologically proven or not).
- Non-opposition of the patient, relative or legal representative.
Exclusion
- Treatment with oral or intravenous iron in the month prior to hospitalization.
- Implementation of a TIPS in the month prior to admission.
- Presence of hepatocellular carcinoma with an expected survival \< 3 months or any other progressive cancer.
- Adult person subject to legal protection (safeguard of justice, curatorship, guardianship), person deprived of liberty.
Key Trial Info
Start Date :
May 17 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04807023
Start Date
May 17 2021
End Date
November 1 2022
Last Update
July 19 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
CHU Rennes
Rennes, France