Status:
WITHDRAWN
Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting.
Lead Sponsor:
Milton S. Hershey Medical Center
Conditions:
Postoperative Nausea and Vomiting
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Postoperative nausea and vomiting (PONV) are common and continue to be persistent problems following general anesthesia. Intranasal lidocaine has been used for the treatment of migraine. The theoretic...
Detailed Description
Postoperative nausea and vomiting (PONV) is a common complication following general anesthesia.\[1\] In the absence of prophylaxis, it can occur in greater than one third of the patients undergoing su...
Eligibility Criteria
Inclusion
- Adults ≥18 years of age
- ASA Physical status I-III
- Ability to provide informed consent
- Pre-surgical COVID-19 negative test
- Elective, non-cardiac surgery under general anesthesia including breast surgery, gynecologic surgery, and minimally invasive abdominal surgery
Exclusion
- Local anesthetic allergy
- Liver diseases
- Pregnancy
- Current tobacco use
- Pre-existing disorders of the gastrointestinal tract
- Use of anti-emetics within 48 h prior to surgery
- Chronic use of anti-cholinergic medication or chronic treatment with opioids
- Any history of nasal pathology (e.g. Nasal ulcer, polyps, and rhinitis)
- Actual surgical time of \<30 min or \>180 min
- Recovery from anesthesia in any location other than PACU
- History of PONV
- History of motion sickness
- Receiving regional blocks for pain management
- Use of total intravenous anesthesia (TIVA) and/or propofol infusion throughout the case
- Aprepitant (Emend) administration
- Non-English speaking patients
Key Trial Info
Start Date :
October 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04810494
Start Date
October 1 2022
End Date
June 30 2023
Last Update
December 12 2022
Active Locations (1)
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1
Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033