Status:
TERMINATED
Timing of Coronary Angiography in NSTE-ACS With ADHF
Lead Sponsor:
Chonnam National University Hospital
Conditions:
Heart Failure
Acute Coronary Syndrome
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
The investigators hypothesized that immediate coronary angiography (CAG) within 2 hours after admission can reduce mortality compared to delayed CAG after stabilization of acute decompensated heart fa...
Detailed Description
Study objective In this study, investigators aim to compare early coronary angiography (CAG \< 2 hours after randomization) and delayed CAG after stabilization of acute decompensated heart failure (AD...
Eligibility Criteria
Inclusion
- Age more than 18 years old
- NSTE-ACS\*
- Pulmonary congestion or edema on chest X-ray
- The definition of NSTE-ACS
- Among patients with typical angina, dyspnea or chest discomfort without definite non-cardiac causes, at least 1 presentations of angina that suggest a NSTE-ACS:
- Rest angina, which is usually more than 20 minutes in duration
- New onset angina that markedly limits physical activity
- Increasing angina that is more frequent, longer in duration, or occurs with less exertion than previous angina
- A 12-lead electrocardiogram should have no ST-segment elevation. Cardiac troponin may elevate (non-ST-segment elevation myocardial infarction) or not elevate (unstable angina pectoris).
Exclusion
- 1\) Cardiogenic shock\* 2) Heart failure of other causes rather than NSTE-ACS 3) Terminal malignancy 4) Life expentancy \< 1 year 5) Pregnancy or lactation
- \* The definition of cardiogenic shock All these criteria should be met
- Systolic blood pressure \< 90 mmHg for 30 minutes, or needing inotropics or vasopressor to maintain systolic blood pressure \> or = 90 mmHg
- Pulmonary congestion on chest X-ray or increased left ventricular filling pressure by cardiac catheterization
- At least one criteria of organ dysfunction - mental obtundation, clammy ski, ogliuria, renal dysfunction, increased level of blood lactate
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2024
Estimated Enrollment :
316 Patients enrolled
Trial Details
Trial ID
NCT04810806
Start Date
April 1 2021
End Date
March 1 2024
Last Update
March 1 2024
Active Locations (1)
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1
Chonnam National University Hospital
Gwangju, South Korea