Status:
UNKNOWN
Clinical Study of the Effect of Methylprednisolone Combined
Lead Sponsor:
Qianfoshan Hospital
Conditions:
Methylprednisolone;Dihydroxypropyltheophylline;One Lung Ventilation;Respiratory Dynamics
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Through the design of RCT study, the preoperative use of drugs (methylprednisolone + dihydroxypropyltheophylline) as intervention measures, the patients undergoing thoracoscopic lobectomy as the main ...
Eligibility Criteria
Inclusion
- 1\. After fully understanding the purpose and significance of the trial, the patients voluntarily participated in the trial and signed the informed consent;
- 2\. The type of operation was general anesthesia and thoracoscopic lobectomy;
- 3\. Age 18-75 years old, including boundary value, gender is not limited;
- 4\. BMI 18-26kg / m2;
- 5\. ASA grade I-II; no mental disorder, normal consciousness, normal communication;
- 6\. No contraindications of methylprednisolone and dihydroxypropyltheophylline.
Exclusion
- 1\. There were diseases of immune, endocrine, nervous and mental system before operation, and serious dysfunction of heart, liver and kidney;
- 2\. Take immunosuppressive drugs and non steroidal anti-inflammatory drugs before operation;
- 3\. Respiratory tract infection (cough, expectoration, suffocation, etc.) in recent 1 month; pneumonia, bronchitis, etc. on CT;
- 4\. History of chronic pulmonary disease, including but not limited to asthma, pulmonary abscess, tuberculosis, chronic bronchitis, etc;
- 5\. FEV1 \< 50%;
- 6\. Oxygen saturation was lower than 90% and airway pressure was higher than 40 cm H20;
- 7\. Continuous hypotension or hypertension during the operation; intraoperative blood loss \> 1000ml;
- 8\. Allergic to methylprednisolone or dihydroxypropyltheophylline;
- 9\. There are any other situations that the researchers think are not suitable for inclusion.
Key Trial Info
Start Date :
July 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2021
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT04810819
Start Date
July 1 2021
End Date
December 30 2021
Last Update
June 16 2021
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