Status:
UNKNOWN
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients
Lead Sponsor:
University Hospital Center of Martinique
Conditions:
Obesity Morbid
Obesity-Associated Insulin Resistance
Eligibility:
FEMALE
18-45 years
Brief Summary
Epidemiological studies show a very rapid increase in the epidemic of obesity in the Caribbean population. 6 out of 10 adults are overweight and 1 out of 4 is obese. Most are women. Consequences : ha...
Detailed Description
Epidemiological studies show a very rapid increase in the epidemic of obesity in the Caribbean population. The latest prevalence data in Martinique show that 6 out of 10 adults are overweight and 1 ou...
Eligibility Criteria
Inclusion
- Being a woman between the ages of 18 and 45;
- Have been well informed about bariatric surgery and perioperative risks and have benefited from a multidisciplinary evaluation by a multidisciplinary team (RCP) ;
- Have a BMI greater than or equal to 40 kg/m2 or greater than or equal to 35 kg/m2 with at least one co-morbidity that can be improved after surgery (cardiovascular disease, sleep apnea and severe respiratory disorders, type 2 diabetes, osteoarticular diseases)
- Have been informed of the research on the samples taken during care;
- Having stated its decision not to object to the research on the samples taken during the treatment;
- To have accepted medical and surgical follow-up for 24 months;
- Patient under the general social security system.
Exclusion
- Being a pregnant or nursing woman;
- Being a type 1 diabetic;
- Have inflammatory bowel disease;
- Have severe and unstable eating disorders ;
- Have severe, uncontrolled cognitive, mental or psychological disorders;
- Have a cancerous pathology;
- Be addicted to alcohol and psychoactive substances (both legal and illegal);
- Have a life-threatening illness in the short or medium term;
- Have contraindications related to surgical operations in general such as general anaesthesia;
- Be under legal protection measures (guardianship, curators, safeguarding of justice), and person deprived of liberty.
Key Trial Info
Start Date :
March 13 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 12 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04814147
Start Date
March 13 2021
End Date
June 12 2025
Last Update
August 28 2023
Active Locations (1)
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1
CHU de Martinique
Fort-de-France, Martinique, 97261