Status:
RECRUITING
Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this project is to analyze the macrophage transcriptome and protein markers of Amyotrophic Lateral Sclerosis (ALS) patients compared to controls (non-affected individuals, patients with oth...
Detailed Description
Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease in adults affecting upper and lower motor neurons resulting in progressive muscle atrophy and paralysis of the patients with...
Eligibility Criteria
Inclusion
- Agree to participate in this research and have signed an informed consent
- Be able to understand the objectives and procedures of the study
- Be affiliated to French social security or equivalent
- Meet one of the criteria below:
- (i) Be affected by Amyotrophic Lateral Sclerosis (ALS) definite, probable or possible (El Escorial criteria) sporadic SALS (no known history in the family) or familial FALS (at least one other member of the family affected), (ii) not being affected by ALS but having a close relative who has or has been diagnosed with ALS and has or is a carrier of a known mutation causing ALS and has consented to a genetic analysis, (iii) Have a motor impairment including the following pathologies: Motor neuropathy, myopathy, Myositis, Spastic paraplegia, Cram / fasciculation syndrome, Chronic inflammatory polyradiculitis, somatization disorder, Anterior spinal artery syndrome, encephalitis, myelitis, Peroneal neuropathy, cervical myelopathy with radiculopathy, spinocerebellar ataxia, Kennedy disease, Spinal atrophy, Hereditary distal motor neuropathy.
- (iv) be accompanying a person with ALS or other motor impairment that is followed by one of the doctors from the ALS referral center at the Pitié-Salpêtrière hospital or by a neurologist from the neurophysiology department at the Pitié-Salpêtrière hospital.
Exclusion
- Be subjected to a legal protection measure (safeguard of justice, curatorship or guardianship)
- Refusing to participate in the study
- Whose condition, in the opinion of the doctor, is incompatible with blood draw or participation in research
- Being pregnant or breastfeeding
Key Trial Info
Start Date :
September 29 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 30 2027
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT04816227
Start Date
September 29 2021
End Date
October 30 2027
Last Update
December 27 2024
Active Locations (1)
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1
Département de Neurologie, Hôpital de la Pitié-Salpêtrière
Paris, France, 75013