Status:
COMPLETED
Drug-drug Interaction Study of Lemborexant as an Adjunctive Treatment for Buprenorphine/Naloxone for Opioid Use Disorder
Lead Sponsor:
Virginia Commonwealth University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Drug Interaction
Analgesics
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this research study is to test the safety, tolerability, drug interactions with buprenorphine-naloxone, and effectiveness lemborexant when used to treat Opioid Use Disorder.
Detailed Description
The purpose of this study is to test the effects of lemborexant when used in combination with opioids (including buprenorphine). We are also interested in learning lemborexant might help improve sleep...
Eligibility Criteria
Inclusion
- Males and females between 18 - 65 years-of-age;
- Understand the study procedures and provide written informed consent in English language;
- Meet current DSM-5 criteria for opioid use disorder, of at least moderate severity, currently engaged medication assisted treatment at a buprenorphine-naloxone sublingual film daily dose ranging from 8mg/2mg to 24mg/6mg or buprenorphine sublingual tablet 5.7mg/1.4mg to 17.1/4.3 once daily for at least last 2 weeks;
- Have a positive urine drug screen for buprenorphine during screening and on admission to the clinical research unit to document buprenorphine use;
- Have a Pittsburgh Sleep Quality Index (PSQI) Total Score of 6 or higher.
Exclusion
- Contraindications for participation as determined by medical history and physical exam performed by study NP or study physician;
- Pregnant or nursing women;
- Baseline ECG with clinically significant abnormal conduction;
- Uncontrolled serious psychiatric or major medical disorder, including COPD. Narcolepsy is also considered exclusionary;
- Taking prescription or over-the counter drugs or dietary supplements known to significantly inhibit CYP3A4 (such as Clarithromycin, telithromycin, nefazodone, itraconazole, ketoconazole, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir), or CYP3A4 inducers (such as phenobarbital, phenytoin, rifampicin, St. John's Wort, and glucocorticoids);
- Prescribed medications for insomnia, or unable to discontinue over the counter drugs or dietary supplements used to treat insomnia on study days.
- Current severe alcohol use disorder or current benzodiazepine use disorder
- Current DSM-5 diagnosis of any psychoactive substance use disorder other than opioids, cocaine, marijuana, or nicotine, or mild or moderate alcohol use disorder. Diagnosis of mild to moderate use disorder for alcohol will not be considered exclusionary.
- Any previous medically adverse reaction to opioids or lemborexant:
- Significant current suicidal or homicidal ideation (C-SSRS "yes" answers on questions 4 or 5) or a history of suicide attempt within the past 6 months.
- Subjects with Suicidal Behaviors Questionnaire-Revised score ≥8 at the screening visit.
- Any other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.
Key Trial Info
Start Date :
May 3 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 20 2023
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT04818086
Start Date
May 3 2021
End Date
April 20 2023
Last Update
November 13 2024
Active Locations (1)
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1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298