Status:
COMPLETED
Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient
Lead Sponsor:
Mahidol University
Conditions:
Sleep Deprivation
Critically Ill
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The investigators proposed that gabapentin will increase slow-wave sleep in adult critically ill patients. Increasing slow-wave sleep will improve the patients' outcomes (shortening ICU length of stay...
Detailed Description
Up to 61% of critically ill patients have sleep deprivation in ICU. Sleep deprivation can cause delirium and lead to prolonged ICU length of stay and mechanical ventilator days. However, pharmacologic...
Eligibility Criteria
Inclusion
- Adults (18 years and older)
- Patients admitted to ICU not more than 24 hours at the time of randomization
Exclusion
- Patients admitted to ICU less than 72 hours
- Patients receiving gabapentin within 14 days prior to randomization
- Patients receiving restorative drug (trazodone, mirtazapine, olanzapine, agomelatine, and pregabalin) within 7 days prior to randomization
- Patients having contraindications to gabapentin
- Patients receiving high dose vasopressors more than 1 hour during ICU admissions
- Patients presenting with severe respiratory failure (PF ratio \< 100)
- Patients presenting with RASS \< -2 at the time of randomization
- Patients having target RASS of \<-2 during ICU admissions
- Terminal ill patients
- Pregnancy
Key Trial Info
Start Date :
April 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04818450
Start Date
April 19 2021
End Date
July 31 2022
Last Update
August 11 2022
Active Locations (1)
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1
Ramathibodi Hospital, Mahidol University
Ratchathewi, Bangkok, Thailand, 10400