Status:
UNKNOWN
Comparison of Bolus Versus Continuous Infusion of Terlipressin Cirrhotic Patients With Septic Shock.
Lead Sponsor:
Institute of Liver and Biliary Sciences, India
Conditions:
Liver Cirrhosis
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Septic shock is a major life-threatening vasodilatory shock. Vasopressor form a crucial pharmacotherapeutic option and have long been used as the first and foremost recommended therapy.(1) However, so...
Detailed Description
Methodology: * Study population: All the consecutive patients of cirrhosis admitted to Intensive care unit of Hepatology department of ILBS will be evaluated for inclusion * Study design: Prospective...
Eligibility Criteria
Inclusion
- \- Cirrhotics including ACLF with septic shock requiring norepinephrine dose \>0.5ug/kg/min to maintain MAP\> 65 mm Hg
- \- An informed consent from the patient or relative
Exclusion
- Patients with age less than 18 years or more than 65 years
- Severe known cardiopulmonary disease (Hypertension, structural or valvular heart disease, coronary artery disease, arrhythmias)
- Stroke
- Peripheral Vascular disease
- Gut Paralysis
- Intestinal obstruction
- Cancer, hepato-cellular carcinoma (HCC), intrahepatic or extrahepatic malignancy
- Portal vein thrombosis
- Hepatic vein outflow tract obstruction (HVOTO )
- Pregnancy
- Patients with Pa02/FiO2 ratio \<150
- Severe coagulopathy platelets \<20,000 and INR \> 4
- Active Bleed (Mucosal or variceal)
- Patients already on terlipressin in the last 48 hours
- Extremely moribund patients with an expected life expectancy of less than 24 hours
- Failure to give informed consent from family members.
- Patient enrolled in other clinical trials
Key Trial Info
Start Date :
June 25 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 19 2022
Estimated Enrollment :
310 Patients enrolled
Trial Details
Trial ID
NCT04819568
Start Date
June 25 2021
End Date
March 19 2022
Last Update
November 10 2021
Active Locations (1)
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1
Institute of Liver & Biliary Sciences
New Delhi, National Capital Territory of Delhi, India, 110070