Status:
UNKNOWN
Safety of UC-MSC Transfusion for ACLF Patients
Lead Sponsor:
Hai Li
Conditions:
Acute-On-Chronic Liver Failure
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
Acute on chronic liver failure (ACLF) is a type of critically ill liver disease with high short-term mortality in liver disease. Liver transplantation is currently the only method to improve survival....
Detailed Description
Acute-on-chronic liver failure (acute-on-chronic liver failure, ACLF) is a special type of rapid deterioration of liver function that occurs on the basis of cirrhosis or non-cirrhosis, which is charac...
Eligibility Criteria
Inclusion
- . Age 18-70 years old;
- . A history of chronic liver disease, chronic acute liver failure (ACLF) caused by various causes, 1-2 organ failure (ACLF diagnosis is based on the European EASL diagnostic criteria, and the organ failure criteria is based on CLIF-OF);
- . The patient or adult family members agree to participate in this study and sign an informed consent form;
Exclusion
- Those who meet any of the following conditions will not be included:
- Those who intend to undergo artificial liver treatment;
- Those who have received liver transplantation and any form of stem cell therapy;
- Malignant tumors in or outside the liver; or imaging findings suggest malignant mass in the liver or tuberculosis;
- Complicated with severe autoimmune diseases; combined with severe cardiopulmonary insufficiency; renal replacement therapy; Immunosuppressive therapy; HIV/tuberculosis infection; alcohol/drug addiction; participated in drug trials in the past 3 months;
- Gastrointestinal bleeding or serious infection occurred in the past one month;
- Pregnant and lactating women;
- Those who do not have the ability to make independent judgments and have no direct adult family members to sign the informed consent form.
Key Trial Info
Start Date :
September 30 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 21 2024
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04822922
Start Date
September 30 2021
End Date
July 21 2024
Last Update
July 21 2021
Active Locations (1)
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1
Ren Ji Hospital, School of Medicine, Shanghai Jiao TongUniversity,
Shanghai, Shanghai Municipality, China