Status:
COMPLETED
4FMFES-PET Imaging of Endometrial and Ovarian Cancers
Lead Sponsor:
Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Collaborating Sponsors:
Université de Sherbrooke
Conditions:
Endometrial Cancer
Ovarian Cancer
Eligibility:
FEMALE
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This project is about exploring a novel method to detect ovarian and uterine cancers earlier and better. More precisely, a high-performance radioactive estrogen analog will be used to visualize hormon...
Detailed Description
Knowledge of estrogen receptor (ER) status is of paramount importance for breast cancer management. Mounting evidence supports an equally important role of ER status for uterine and ovarian cancers. I...
Eligibility Criteria
Inclusion
- Women who received a biopsy-confirmed diagnosis of a ER+ endometrial cancer, or;
- Women with a suspected ovarian cancer, or;
- Women with recurrent endometrial or ovarian cancer and with a ER+ primary tumor, and;
- Planned surgery, and;
- Stage 1A cancer and more, with primary more than 1 cm, and;
- Able to tolerate supine position, and;
- Written consent given by the patient.
Exclusion
- Pregnancy, or;
- Replacement hormone therapy concomitant to 4FMFES-PET, or;
- Use of estrogen-based oral contraceptives concomitant to 4FMFES-PET, or;
- Anti-tumor hormone therapy that compete with estrogen receptors concomitant to 4FMFES-PET, such as tamoxifen and fulvestrant. Withdrawal of such therapies 8 weeks prior to the 4FMFES-PET scan will enable the patient to the imaging test, or;
- Cirrhosis, acute or chronic hepatitis, or any other hepatic problem that might impede the normal elimination of the PET tracer, or;
- Hypersentivity to either FDG or 4FMFES, or any of their consittuants.
Key Trial Info
Start Date :
September 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2024
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT04823065
Start Date
September 1 2018
End Date
April 30 2024
Last Update
May 13 2024
Active Locations (1)
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1
Centre de recherche du CHUS
Sherbrooke, Quebec, Canada, J1H 5N4