Decentrialz logo
  • HIPAA Compliant
  • ISO 27001 Certified
Find Trials
About UsContact
Become a Volunteer+1 877 705 1914

Status:

COMPLETED

Determining the Presence of RAP in Orthognathic Patients and Its Effect on Root Resorption by Biomarkers

Lead Sponsor:

Bezmialem Vakif University

Conditions:

Class III Malocclusion

Root Resorption

Eligibility:

All Genders

18-40 years

Brief Summary

A prospective clinical trial to what extent inflammatory biomarkers are affected by the medication after orthognathic surgery in early surgical cases and whether these biomarkers affects the amount of...

Detailed Description

To conduct a prospective clinical trial to what extent inflammatory biomarkers such as OPG, RANKL, IL-1, IL-6, and CRP are affected by the medication after orthognathic surgery in early surgical cases...

Eligibility Criteria

Inclusion

  • Inclusion Criteria
  • Have skeletal Cl III malocclusion
  • Wisdom teeth are absent or extracted at least 6 months before the surgery
  • Need of orthognathic surgery through Le Fort I osteotomy of the maxilla and bilateral sagittal split osteotomies (BSSO) of the mandible.
  • Undergo fixed orthodontic treatment before and after the orthognathic surgery
  • Have available orthopantomograms with adequate quality
  • Have healthy periodontal tissue without inflammation or bleeding before and after the surgery.
  • Maintain the same medication protocol during and after the surgery.
  • Exclusion Criteria:
  • ongoing use of regular medication
  • smoking
  • known penicillin allergy,
  • any immune disorder,
  • musculoskeletal diseases,
  • syndromes,
  • cleft lip-palate,
  • systemic diseases affecting root resorption,
  • periodontal and gingival disorders,
  • missing teeth among upper or lower incisors,
  • poor oral hygiene.

Exclusion

    Key Trial Info

    Start Date :

    January 5 2019

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ACTUAL

    End Date :

    January 1 2021

    Estimated Enrollment :

    13 Patients enrolled

    Trial Details

    Trial ID

    NCT04823325

    Start Date

    January 5 2019

    End Date

    January 1 2021

    Last Update

    March 30 2021

    Active Locations (1)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 1 (1 locations)

    1

    Banu Kilic

    Istanbul, Fatih, Turkey (Türkiye), 34844