Status:
UNKNOWN
Assessment of Effectiveness and Safety of Transcranial Magnetic Stimulation (rTMS) Combined With Transcranial Direct Current Stimulation (tDCS) in Dementia Treatment in Alzheimer's Disease
Lead Sponsor:
Medical University of Lodz
Conditions:
Alzheimer Disease
Eligibility:
All Genders
55-90 years
Phase:
NA
Brief Summary
Alzheimer's disease is the most common disease responsible for dementia, accounting for 40-70% of all dementia cases. Alzheimer's disease is characterized by a gradual and slow decline in memory and o...
Eligibility Criteria
Inclusion
- Patients with mild to moderate dementia in Alzheimer's disease, diagnosed using DSM-5 criteria.
- MMSE score from 12 to 26 points
- ADAS-Cog over 17 points
- Voluntary consent to participate in the study
- there is a related person or legal guardian who consented to assist the patient in the course of the study
- Minimum 8 years of education.
- It is allowed to use cholinesterase inhibitors and / or memantine for at least 3 months prior to study entry and at a stable dose for at least 60 days prior to study entry.
Exclusion
- Severe agitation
- Intellectual Disability
- Informed consent is not possible
- Unstable somatic condition
- Use of benzodiazepines or barbiturates 2 weeks prior to screening
- Participation in a clinical trial with coinciding factors within 6 months prior to the start of the trial
- Seizures
- Contraindications to rTMS treatment according to the rTMS questionnaire attached to the protocol
- Contraindications to tDCS treatment according to the tDCS questionnaire attached to the protocol
- Patients with depression, bipolar, or psychotic disorders, or any other neurological or psychiatric condition (current or past) that the Investigator considers to be interfering with the study
- Alcoholism or drug addiction as defined by DSM-5 in the last 5 years (addicted for more than a year and or in remission for less than 3 years)
- Patients with any medical condition that the Investigator considers to be an exclusion criterion from the study
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04823819
Start Date
April 1 2021
End Date
September 30 2023
Last Update
May 27 2021
Active Locations (1)
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1
Department of Old Age Psychiatry and Psychotic Disorders Medical University of Lodz
Lodz, Poland, 92-213