Status:
UNKNOWN
The Use of Injectable Plasma Versus the Use of Simvastatin Gel in Surgical Management of Bony Defect in Dentistry
Lead Sponsor:
Ain Shams University
Conditions:
Intra-bony Pockets
Eligibility:
All Genders
25-40 years
Phase:
PHASE1
Brief Summary
Simvastatin (SMV) is one of the family members of statins, it has been showed in many previous studies that the simvastatin when dissolved with methylcellulose in situ gel with a concentration of 1.2%...
Detailed Description
Group I ( Experimental group): will include 12 patients undergoing open flap debridement (OFD) followed by single application of I-PRF. Oral Hygiene measure will be instructed following treatment and ...
Eligibility Criteria
Inclusion
- • Age range between 25 and 40 years
- Patients with severe chronic periodontitis having probing depth (PD) ≥6 mm and clinical attachment loss (CAL) ≥5 mm , or Stage III periodontitis
- Patient having vertical bone loss ≥3 mm (distance between alveolar crest and base of the defect as confirmed by preoperative intraoral periapical radiographs using standardized parallel technique.)
- Good compliance with the plaque control instructions following initial therapy
- Availability for follow up and maintenance program.
Exclusion
- • Patient with any systemic disease or conditions
- Patient using antibiotic, anti-inflammatory, and immunosuppressive therapy during the preceding 3 months before the start of trial and during the study.
- Patients who have undergone any periodontal treatment in the last 6 months
- Pregnant and Lactating.
- Reported allergy to any type of statins
- Subjects who were tobacco or alcohol users
- Vulnerable group of patients (e.g.: prisoners , handicapped , or decisionally impaired individuals )
Key Trial Info
Start Date :
January 20 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 20 2022
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04824898
Start Date
January 20 2021
End Date
September 20 2022
Last Update
April 1 2021
Active Locations (1)
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1
Ain Shams University
Cairo, New Cairo, Egypt, 1234