Status:
COMPLETED
Ultrasound-Assessed Diaphragmatic Dysfunction as a Predictor of Weaning Outcome
Lead Sponsor:
Ain Shams University
Conditions:
Weaning Failure
Sepsis
Eligibility:
All Genders
18-60 years
Brief Summary
This study aims to assess whether the degree of diaphragm excursion and diaphragm thickening measured by ultrasound during a weaning trial may be used to predict successful weaning from mechanical ven...
Detailed Description
After being informed about the study and giving written informed consent, Intubated and mechanically ventilated patients with sepsis on admission and fulfilling criteria of weaning from mechanical ven...
Eligibility Criteria
Inclusion
- Patients of both sexes, aging 18 - 60 years after written informed consent
- Patients with sepsis on admission according to the new sepsis definition in 2016 (life-threatening organ dysfunction due to a dysregulated host response to infection)
- Hemodynamically stable without or with low dose support
- Patients on mechanical ventilation for at least 48 hours and not more than 1 week
- Patients ready for start of weaning protocol, fully conscious, on continuous positive airway pressure (CPAP) mode with positive end expiratory pressure (PEEP) 3-5 Centimetre water (CmH2O), Pr. Supp. \<15 CmH2O, Fio2 less than 60%, Respiratory rate less than 35 breath/min, partial oxygen pressure (PO2)/FIO2 \>200, Rapid Shallow Breathing Index (RSBI) is less than 105
Exclusion
- Patients aged less than 18 years or more than 60 years old
- Patients in septic shock, hemodynamically unstable or on high dose support
- Patients on mechanical ventilation for more than 1 week or less than 48 hours
- Patients not ready for start of weaning from mechanical ventilation
- Patients with neuromuscular disorders
- Pregnant females in the second and third trimester, patients with tense ascites or morbidly obese with body mass index more than 40 kg/m2
Key Trial Info
Start Date :
April 18 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04825509
Start Date
April 18 2021
End Date
November 1 2021
Last Update
July 21 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Ain Shams University Hospital
Cairo, Egypt, 11591