Status:

COMPLETED

Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)

Lead Sponsor:

University of British Columbia

Collaborating Sponsors:

Edwards Lifesciences

Conditions:

Aortic Stenosis

Aortic Valve Stenosis

Eligibility:

All Genders

Brief Summary

The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized In...

Detailed Description

Since the introduction of Doppler echocardiography, non-invasive estimation of aortic valve gradients through modification and simplification of the Bernoulli equation and derivation of the AVA, via t...

Eligibility Criteria

Inclusion

  • Echocardiographic transaortic mean gradient ≥ 20mmHg OR VARC-3 criteria for ≥ moderate hemodynamic valve deterioration post TAVR on any TTE \> 1 month post-TAVR
  • Consensus by the Heart Team that the patient is suitable for Standardized Invasive Hemodynamics (SIH).

Exclusion

  • CT demonstrating leaflet thrombosis or hypoattenuated leaflet thickening (HALT)

Key Trial Info

Start Date :

August 30 2021

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

June 20 2025

Estimated Enrollment :

49 Patients enrolled

Trial Details

Trial ID

NCT04827238

Start Date

August 30 2021

End Date

June 20 2025

Last Update

July 24 2025

Active Locations (9)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 3 (9 locations)

1

PIMA Heart Centre

Tucson, Arizona, United States, 85712

2

Tenet Health

Boca Raton, Florida, United States, 33484

3

eCommunity

Indianapolis, Indiana, United States, 46256

4

Community Hospital

Munster, Indiana, United States, 46321