Status:
COMPLETED
The Effect of Closed-Loop Versus Conventional Ventilation on Mechanical Power
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborating Sponsors:
Reinier de Graaf Groep
Dijklander Ziekenhuis
Conditions:
Mechanical Ventilation
Mechanical Power
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Several studies suggest fully-automated ventilation to ventilate with a lower amount of MP in unselected ICU patients, patients after cardiac surgery, and patients with and without ARDS. The current s...
Detailed Description
Rationale: Mechanical ventilation can cause ventilator-induced lung injury (VILI). Lung protective ventilation, consisting of a low tidal volume (VT), a low plateau pressure (Pplateau) and a low driv...
Eligibility Criteria
Inclusion
- Admitted to one of the participating ICUs;
- Receiving invasive ventilation through a standard endotracheal (i.e., oral) tube;
- Expected to be ventilated \> 24 hours; and
- Ventilation is applied by a ventilator that can provide INTELLiVENT-ASV and conventional ventilation.
Exclusion
- Age under 18 years;
- No written informed consent;
- Morbidly obese; and
- Any contra-indication for use of INTELLiVENT-ASV
Key Trial Info
Start Date :
July 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2023
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT04827927
Start Date
July 5 2021
End Date
July 1 2023
Last Update
August 24 2023
Active Locations (3)
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1
Academic Medical Center
Amsterdam, North Holland, Netherlands, 1105 AZ
2
Reinier de Graaf Gasthuis
Delft, Netherlands
3
Dijklander Ziekenhuis
Hoorn, Netherlands