Status:
COMPLETED
Covid-19 Vaccine Responsiveness in MM and Waldenstrom
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Multiple Myeloma
Waldenstrom Macroglobulinemia
Eligibility:
All Genders
18+ years
Brief Summary
This research is being done to see if the immune (defense) system of people with Multiple Myeloma and Waldenstrom's Macroglobulinemia reacts to the COVID-19 vaccine.
Detailed Description
COVID-19 vaccines are designed to help prevent infections, hospitalizations, and death from the COVID-19 virus. Normally, when the vaccine is administered, the immune system reacts by creating antibod...
Eligibility Criteria
Inclusion
- Age \>18 years.
- Lack of a contra-indication to a currently available COVID-19 vaccine.
- Diagnosis of MM according to International Myeloma Working Group (IWMG) criteria (Cohort 1) or Diagnosis of WM according to WHO criteria (Cohort 2)
- For treatment naïve WM patients (Cohort 2A):
- Patient must have no prior history of anticancer treatment for WM.
- The treating investigator must have no intention to initiate WM therapy within 2 months
- For WM patients receiving BTK inhibitor (Cohort 2B):
- Patient must have no history of cytotoxic chemotherapy within 1 year, and no history of other anticancer therapy within 6 months.
- For currently or previously treated WM patients (Cohort 2C):
- Patient must not be currently taking a BTK inhibitor or had recent exposure within 1 month of enrollment. Current or prior history of any other WM-directed therapy is allowed.
Exclusion
- \-
Key Trial Info
Start Date :
April 15 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 14 2022
Estimated Enrollment :
146 Patients enrolled
Trial Details
Trial ID
NCT04830046
Start Date
April 15 2021
End Date
September 14 2022
Last Update
November 26 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215
2
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215